Carbohydrates are not only nutrition like table sugar and starch or stabilising material like cellulose or chitin (in crab shells). Specific carbohydrate structures are found on (every) cell surfaces of both humans and microorganisms that have important biological functions involved with the interaction of the cells with the surrounding environment.
We are interested in the chemical synthesis of:
- Saccharides found in bacteria and fungi, for the development of vaccines
- Human cell surface structures to investigate the role they play in pathogenesis
- Cancer cell surface carbohydrate structures to try to understand their role in cancer development
- Synthetic heparin structures for investigations as improved anti-coagulants