Projects

vaccinesVaccine Projects

Synthesis and immunological evaluation of CPS and LPS-based glycoconjugate vaccines against microbial pathogens such as Neisseria meningitidis, Moraxella cattarrhalis, and Cryptococcus neoformans. 

proteincarbintLectin Projects

Synthesis of libraries of modified carbohydrate oligosaccharides for the investigation of lectin-glycans interactions, in particular galectins, sigles, mannose-binding lectins, and microbial lectins (H. pylori, A. fumigatus, Lactococcal bacteriophages). 

mucoliticMucolytic Project

Synthesis of carbohydrate-based mucolytics as a potential new therapy to liquefy thickened mucus in cystic fibrosis patients.

heparinHeparin Project

Synthesis of heparin based oligosaccharides for investigations into the role heparin cofactor II plays in the blood coagulation cascade, and synthesis of  the active pentasaccharide related to heparin  as an anticoagulant.

 

 

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